| Date | Location | Result | |
| 2/25/06 | Evansville, IN/PAC | Missouri-St. Louis 61, Southern Indiana 56 | Box score |
| 2/23/06 | Evansville, IN/PAC | Missouri-Rolla 80, Southern Indiana 73 | Box score |
| 02/18/06 | Edwardsville, Ill./Vadalabene Center | Southern Indiana 76, SIU Edwardsville 68 | Box score |
| 2/16/06 | Pepsi Arena, Quincy, Illinois | Quincy 85, Southern Indiana 69 | Box score |
| 2/11/06 | Evansville, IN/PAC | Southern Indiana 82, Rockhurst 74 | Box score |
| 2/9/06 | Evansville, IN/PAC | Drury 89, Southern Indiana 61 | Box score |
| 02/04/06 | Owensboro Sportscenter, Owensboro, Ky. | Kentucky Wesleyan 85, Southern Indiana 75 | Box score |
| 1/28/06 | Evansville, IN/PAC | Southern Indiana 90, Saint Joseph's 83 | Box score |
| 1/26/06 | Evansville, IN/PAC | Indianapolis 71, Southern Indiana 63 | Box score |
| 01/21/06 | Rockhurst University | Southern Indiana 77, Rockhurst 63 | Box score |
| 1/19/06 | Springfield, Missouri/Weiser Gym | Drury Lady Panthers 79, Southern Indiana 59 | Box score |
| 1/14/06 | Evansville, IN/PAC | Southern Indiana 70, SIU Edwardsville 69 | Box score |
| 1/12/06 | EVANSVILLE, IN/PAC | Quincy 75, Southern Indiana 61 | Box score |
| 1/7/06 | Highland Heights, Ky. | Northern Kentucky University 62, Southern Indiana 43 | Box score |
| 1/5/06 | Louisville, Ky. (Knights Hall) | Bellarmine University 83, Southern Indiana 77 | Box score |
| 1/2/06 | Evansville, IN/PAC | Southern Indiana 85, Alabama-Huntsville 79 | Box score |
| 12/31/05 | Evansville, IN/PAC | Southern Indiana 100, Oakland City 70 | Box score |
| 12/20/05 | Evansville, IN/PAC | Southern Indiana 66, Purdue-Calumet 36 | Box score |
| 12/18/05 | Evansville, IN/PAC | Southern Indiana 82, Wayne State 66 | Box score |
| 12/10/05 | Evansville, IN/PAC | Lewis 71, Southern Indiana 57 | Box score |
| 12/8/05 | Evansville, IN/PAC | Southern Indiana 72, Wisconsin-Parkside 42 | Box score |
| 12/03/05 | Southern Indiana 58, Missouri-St. Louis 52 | Box score | |
| 12/1/05 | Rolla, Mo. (Bullman Multi-Purpose Bldg.) | Missouri-Rolla 60, Southern Indiana 47 | Box score |
| 11/27/05 | Evansville, IN (Physical Activities Ctr) | Southern Indiana 73, WV Wesleyan 60 | Box score |
| 11/22/05 | Evansville, IN\PAC Arena | Southern Indiana 74, Central State 38 | Box score |
| 11/20/05 | Evansville, IN (Physical Activities Ctr) | Southern Indiana 66, Northwood University 55 | Box score |
| 11/15/05 | Evansville, IN/PAC Arena | Southern Indiana 87, Brescia 62 | Box score |
| 11/06/05 | Disney's Wide World of Sports | AUGUSTA ST. UNIV. 66, Southern Indiana 55 | Box score |
| 11/05/05 | Disney's Wide World of Sports | MERRIMACK COLLEGE 72, Southern Indiana 58 | Box score |
| 11/04/05 | Disney's Wide World of Sports | COLUMBUS ST. UNIV. 78, Southern Indiana 62 | Box score |